A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects

Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution. The active cancer treatment ingredient disulfiram (DSF), inspired by the copper(II) diethyldithiocarbamate complex (CuET), can be used in a one-pot synthesis method to construct a CuET delivery nanosystem (CuET-ZIF_Cu@HA). Due to the high biocompatibility, targeting of CD44 overexpressed cancer cells, and acid response of zeolitic imidazolate framework (ZIF) materials of hyaluronic acid (HA), we realized that CuET-ZIF_Cu@HA could become an effective and highly selective cancer treatment. Both in vivo and in vitro experiments have demonstrated that CuET-ZIF_Cu@HA has robust anti-tumor properties without evident side effects. This research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy, both of which are key to reusing DSF in cancer treatment.     

Deep Integration of Innovation and Entrepreneurship (InE) Education in Chinese University Classrooms

Recently, InE has been regarded as a popular education strategy in Chinese universities. However, problems have been exposed in the adoption of InE, for example, in InE courses and competitions. The purpose of this paper is to provide a possible solution to the problems, which is to organize effective InE courses by integrating InE with Inter-Course-level Problem-Based Learning (ICPBL). A detailed case is demonstrated by an ICPBL elective course design with deep integration of InE in the teaching, learning, and assessments. This paper contributes to a new curriculum design for promoting InE education in practically for Chinese universities.     

Btk/JAK3双靶点共价抑制剂的设计、合成及其活性研究

布鲁顿式酪氨酸激酶(Btk)和两面神激酶3(JAK3)均是自身免疫性疾病和血液系统恶性肿瘤的潜力靶标。以4-氯吡咯并嘧啶为原料,经7步反应合成了一系列7H-吡咯并[2,3-d]嘧啶-4-胺衍生物,其结构经¹HNMR、¹³CNMR和MS(ESI)分析证实。体外依次考察了所得化合物分别对Btk和JAK3激酶的活性、以及对部分B淋巴细胞瘤细胞系的抗增殖活性。结果表明,四氢吡咯烷基取代的衍生物NB1~4对Btk(IC₅₀<3 nmol/L)和JAK3(IC₅₀<165 nmol/L)均能有效抑制,其余化合物只对Btk显示抑制效果;而且NB2和NB4对所测试的多种B细胞淋巴瘤细胞系的抗增殖活性均优于阳性对照泛激酶抑制剂依鲁替尼及Btk单靶点抑制剂。其中,对Jeko-1细胞的抑制能力最佳(IC₅₀<3μmol/L),其次是OCI-LYI(IC₅₀<4μmol/L)、SUDHL-6(IC₅₀<6μmol/L)和HBL-1^*(IC₅₀<6.5μmol/L),最差为SUDHL-4细胞(IC₅₀<11μmol/L)。这些发现可为开发B细胞淋巴瘤的多靶点药物提供新的思路。     

Orientation Dependence of the Micro-Pillar Compression Strength in an Electron Beam Melted Ti–6Al–4V Alloy

An α/β two-phase Ti-6 Al-4 V alloy was fabricated by electron beam melting to obtain a basketweave structure.The orientation dependence of the mechanical properties of Ti-6 Al-4 V alloy was studied by micro-pillar compression and post-mortem transmission electron microscopy analysis.The results indicate that different grains have different mechanical responses,and the possible attributions were discussed.Besides the orientation effect,due to the limited volumes of micropillars,the size of the a phases,dispersion of the β phases,and the presence of the free dislocation path also affect the mechanical properties of the micropillars to a large extent.Although no direct link was discovered between the mechanical properties and the parent βorientations,this work provided a promising method to further study the anisotropic mechanical behavior in Ti-6 Al-4 V alloy.     

Enhanced electrode kinetics and electrochemical properties of low-cost NaFe2PO4(SO4)2 via Ca2+doping as cathode material for sodium-ion batteries

In recent years,sodium-ion batteries(SIBs)have been considered as one of the most promising alterna-tives to lithium-ion batteries(LIBs).Here,a new Na-super-ionic conductor(NASICON)cathode material NaFe2PO4(SO4)2 is successfully prepared through solid state method for SIBs.While the poor electronic conductivity of iron-based materials results in its poor rate and cycle performance.Then the electro-chemical is effectively promoting via Ca2+doping.Na0.84Ca0.08Fe2PO4(SO4)2 have achieved considerable electrochemical properties.The first discharge specific capacity is 121.6mAhg-1 at 25mAg-1 with the voltage platform(～3.1 V)corresponding to Fe2+/3+.After 100 cycles,the capacity retention is 55.1％.The excellent electrochemical performance is caused by some Na+is substituted by Ca2+and leading to the fast sodium kinetics,which is well proved by the powder X-ray diffraction pattern and well corresponding to the galvanostatic intermittent titration technique and cyclic voltammetry testing result(the diffusivity values are around at 10-12 cm2 s-1).     

A digital-twin visualized architecture for Flexible Manufacturing System

The new generation of industrial 4.0 intelligent manufacturing system consists of Human-Cyber-Physical System (HCPS), integrating human with cyber and physical systems. In manufacturing, a digital-twin visualization architecture is to solve the human-machine interaction problem that concerns digital-twin modeling on the Cyber-Physical (C-P) side and on the Human-Cyber side. Although there are many related research and applications, there lacks attention in terms of full life cycle functional services and lightweight architecture. This paper presents a general architecture of digital-twin visualization for flexible manufacturing systems (FMS). How the digital-twin C-P modeling of multi-source heterogeneous information can be described is investigated and how the 3D visualized human-machine interaction with digital-twin scenario information is explored in the proposed architecture. Besides, the visualization method of high-value information, relating to the life cycle planning, design, debugging and service stages, is studied and discussed thoroughly. Also, a digital-twin modeling concept of "Geometric information (G)-Historical samples (H)-Object attribute (O)-Snapshot collection (S)-Topology constraint (T)" (GHOST) is proposed, and methods for developing virtual digital-twin scenes architecture are presented. Based on the proposed modeling concept of GHOST for digital-twin, prototypes have been developed for the general platform of digital-twin RESTful services and the cross-platform general visual mock-up software. Experimental results show that this method is effective in the FMS lifecycle in various aspects.     

Impact of the SiC addition on the morphological,structural and mechanical properties of Cu-SiC composite powders prepared by high energy milling

The effect of the SiC content on the microstructural, mechanical, and magnetic properties of Cu(1 − x)SiC(x) composite powders (x = 0, 2, 10 and 15 wt%) prepared by high energy milling for 30 h was investigated. The results showed that Cu particles were severely deformed and formed plate like particles of different sizes, while SiC particles were fragmented and embedded in the Cu phase, thus, forming composite particles. As the SiC content increased, the average particle size decreased from 40.75 to 12.84 µm. Besides, XRD data showed a decrease in the crystallite sizes of the Cu phase (from 23.66 to 21.56 nm), accompanied by an increase in the lattice micro-strain (from 0.41 to 0.46%). Changes in the lattice parameters of the Cu phase were observed. The Vickers microhardness were measured in compacted powder samples and reached a maximum value of 135.22 HV for the sample with 15 wt% SiC. The samples showed hysteresis magnetic behavior at 300 K, and with a maximum saturation magnetization of 0.123 emu/g. The weak magnetic signal is mainly due to Co impurities present in the WC from the milling media.     

Customers segmentation in eco-friendly hotels using multi-criteria and machine learning techniques

This study aims to investigate the travellers' choice behaviour towards green hotels through existing online travel reviews on TripAdvisor. Accordingly, a method combining segmentation and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) techniques was developed to segment travellers based on their provided reviews and to prioritize green hotel attributes based on their level of importance in each segment. The data were taken from travellers' online reviews of Malaysian eco-friendly hotels on TripAdvisor. The results showed that the sleep quality was one of the most imporant factors for eco-hotel selection in the majority of segments. The developed method in this study was able to analyse travellers’ reviews and ratings on eco-friendly hotels to identify the future choice behaviour and aid travellers in their decision-making process. The study provides new insights for hotel managers and green policy makers on developing environmental-friendly practices.